Nuclear Receptors in Breast Cancer
The Nuclear Receptors in Breast Cancer (NRBC) research project is focused on the identification of new therapeutic targets for breast cancer treatment.
Given the success of treatments targeting the oestrogen receptor (ER) in breast cancers expressing this gene, the NRBC project seeks to identify other nuclear receptors that may be targeted to improve the treatment outcomes for patients whose cancer is negative for ER.
Building on the experimental discovery program of the NRBC project, QFAB researchers are currently conducting detailed computational analyses of nuclear receptor networks in order to discover mechanisms of cross-talk between other nuclear receptors and ER.
Computational discovery of potential downstream targets of the nuclear receptors will enable the targeted experimental investigation of key genes, and facilitate the identification of new therapeutic targets for the treatment of breast cancer.
Translational Research Case Studies